中药与方剂结构化数据集

{
  "tcm_id": "TCM-2025-R8F2L4K9B6",
  "chinese_name": "附子",
  "latin_name": "Aconitum carmichaelii Debx.",
  "family": "毛茛科 Ranunculaceae",
  "medicinal_part": "子根",
  "nature_flavor": {"four_qi": "大热", "five_flavors": ["辛", "甘"], "toxicity": "有毒"},
  "channel_tropism": ["心经", "肾经", "脾经"],
  "efficacy_category": "温里药",
  "efficacy": "回阳救逆，补火助阳，散寒止痛",
  "processing_methods": [
    {"method": "盐附子", "description": "选大个净附子，浸入食盐和盐卤混合液中，每日晾晒并逐渐延长晾晒时间"},
    {"method": "黑顺片", "description": "取泥附子，浸入胆巴水中数日，煮至透心，纵切成约5mm厚片，调色干燥"},
    {"method": "白附片", "description": "取泥附子，浸入胆巴水中数日，煮至透心，去皮，纵切成约3mm厚片，蒸透晒干"}
  ],
  "toxicity_management": {
    "toxic_component": "双酯型二萜生物碱（乌头碱、新乌头碱、次乌头碱）",
    "detoxification_principle": "炮制使双酯型生物碱水解为单酯型（毒性降为1/200）",
    "contraindications": "孕妇禁用；不宜与半夏、瓜蒌、天花粉、川贝母、浙贝母、白蔹、白及同用"
  },
  "chemical_constituents": ["乌头碱", "新乌头碱", "次乌头碱", "附子多糖"],
  "version": "2025Q1",
  "quality_score": 96.8
}

{
  "formula_id": "FML-2025-H2S7P9R4A6",
  "formula_name": "麻黄汤",
  "source": "《伤寒论》",
  "author": "张仲景",
  "category": "解表剂/辛温解表",
  "composition": [
    {"drug": "麻黄", "dose": "三两", "role": "君药"},
    {"drug": "桂枝", "dose": "二两", "role": "臣药"},
    {"drug": "杏仁", "dose": "七十个", "role": "佐药"},
    {"drug": "炙甘草", "dose": "一两", "role": "使药"}
  ],
  "modern_dosage": {"doses": [{"麻黄": "6-10g"}, {"桂枝": "6-10g"}, {"杏仁": "6-10g"}, {"炙甘草": "3-6g"}]},
  "efficacy": "发汗解表，宣肺平喘",
  "indications": "外感风寒表实证。恶寒发热，头身疼痛，无汗而喘，舌苔薄白，脉浮紧。",
  "administration": "水煎服，温覆取微汗。若一服汗出病差，停后服，不必尽剂。",
  "formula_verse": "麻黄汤中用桂枝，杏仁甘草四般施，发热恶寒头项痛，喘而无汗服之宜。",
  "modifications": [
    {"condition": "喘急胸闷、咳嗽痰多", "modification": "加苏子、半夏，名苏子麻黄汤，增强化痰降逆"},
    {"condition": "兼湿、头身疼痛较重", "modification": "加白术，名麻黄加术汤，发汗解表兼以祛湿"}
  ],
  "modern_applications": ["上呼吸道感染", "支气管哮喘急性发作", "流行性感冒（风寒证）"],
  "pharmacology_summary": "麻黄碱兴奋β受体扩张支气管；桂皮醛扩张血管促进发汗；苦杏仁苷镇咳平喘。",
  "version": "2025Q1",
  "quality_score": 98.0
}

{
  "formula_id": "FML-2025-HIP-0012",
  "formula_name": "益气活血合剂",
  "formula_type": "医院备案自制剂",
  "institution": "XX省中医院",
  "record_number": "粤药制字Z202XXXXXXXX",
  "approval_date": "2023-11-20",
  "dosage_form": "合剂（口服液）",
  "specification": "每支10ml，每盒10支",
  "composition": [
    {"drug": "黄芪", "dose": "30g"},
    {"drug": "丹参", "dose": "15g"},
    {"drug": "川芎", "dose": "10g"},
    {"drug": "赤芍", "dose": "10g"},
    {"drug": "红花", "dose": "6g"},
    {"drug": "甘草", "dose": "6g"}
  ],
  "efficacy": "益气活血，化瘀通络",
  "indications": "用于气虚血瘀所致的胸痹心痛，症见胸闷、胸痛、心悸气短；冠心病心绞痛见上述证候者。",
  "dosage": {"adult": {"dose": "1-2支", "frequency": "TID"}},
  "contraindications": "孕妇禁用；有出血倾向者慎用",
  "quality_control": "HPLC指纹图谱: 黄芪甲苷 ≥ 0.30mg/ml; 丹酚酸B ≥ 1.0mg/ml",
  "version": "2025Q1",
  "quality_score": 95.5
}

{
  "tcm_id": "TCM-2025-S6F9W2T8R4",
  "chinese_name": "当归",
  "latin_name": "Angelica sinensis (Oliv.) Diels",
  "family": "伞形科 Apiaceae",
  "medicinal_part": "根",
  "nature_flavor": {"four_qi": "温", "five_flavors": ["甘", "辛"], "toxicity": "无毒"},
  "channel_tropism": ["肝经", "心经", "脾经"],
  "efficacy_category": "补虚药/补血药",
  "efficacy": "补血活血，调经止痛，润肠通便",
  "processing_methods": [
    {"method": "净当归", "description": "除去杂质，洗净，润透，切薄片，晒干或低温干燥"},
    {"method": "酒当归", "description": "取净当归片，加黄酒拌匀，闷透，文火炒干（每100kg用黄酒10kg）"}
  ],
  "geo_authentic_regions": ["甘肃岷县", "甘肃宕昌", "云南丽江"],
  "chemical_constituents": ["藁本内酯(ligustilide)", "阿魏酸(ferulic acid)", "当归多糖"],
  "pharmacology": {
    "activity": ["促进造血", "抗血栓形成", "调节子宫平滑肌", "抗炎镇痛"],
    "targets": ["COX-2", "TXA2"]
  },
  "formula_associations": [
    {"formula_name": "四物汤", "source": "《太平惠民和剂局方》", "role": "君药"},
    {"formula_name": "当归补血汤", "source": "《内外伤辨惑论》", "role": "臣药（重用黄芪）"}
  ],
  "version": "2025Q1",
  "quality_score": 98.2
}